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. 2013 May 1;38(9):1816–1824. doi: 10.1038/npp.2013.81

Figure 1.

Figure 1

URB597 reverses phencyclidine (PCP)-induced social withdrawal in a CB1-dependent manner, but reduced social interaction in control animals in a CB1-independent manner. (a) URB597 (U; 0.1–1.0 mg/kg, i.p.) affects social interaction in saline- and PCP-treated rats dose-dependently (F3,56=40.5, p<0.0001). (b) Effects of AM251 (1 mg/kg, i.p.) or capsazepine (CPZ; 10 mg/kg, i.p.) on PCP- and URB597-induced changes in social interaction (all two-way interactions F1–2,84>5.28, p<0.01). (c) SR141716 (SR; 0.1 mg/kg, i.p.) reverses URB597-induced social withdrawal in saline-treated rats (all main effects F1,28>6.10, p<0.05). (d) Effects of CPZ (10 mg/kg, i.p.) and URB597 (1 mg/kg, i.p.) coadministration on PCP-induced social withdrawal and its reversal by AM251 (1 mg/kg, i.p.; F4,35=15.5, p<0.0001). Values are expressed as mean±SEM. (n=8 per group) of the time spent in social interaction(s). *p<0.05 compared with saline-treated rats; #p<0.05 compared with URB597 vehicle (V) controls; ¤p<0.05 compared to AM251 or CPZ vehicle (VEH) controls; §p<0.05.