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. 2013 May 1;38(9):1816–1824. doi: 10.1038/npp.2013.81

Figure 3.

Figure 3

Endocannabinoid levels in rats undergoing social interaction. Effects of URB597 (U) in saline- and phencyclidine (PCP)-treated rats on anandamide (AEA, left) and 2-arachidonyl glycerol (2-AG; right) levels in the medial prefrontal cortex (mPFC; main effects F1,22>22.6, p<0.0001 and Treatment effect F1,24=7.7, p<0.05 for AEA and 2-AG, respectively; a), amygdala (amy; main effects F1,24>132.6, p<0.0001 for AEA; b), nucleus accumbens (NAc; F1,23=10.0, p<0.001 and F1,24=4.3, p<0.05 for AEA and 2-AG, respectively; c) and caudate-putamen (CPu; F1,22=0.0, NS and F1,23=6.8, p<0.05 for AEA and 2-AG, respectively; d). The dashed line represents AEA or 2-AG levels in saline-treated animals not undergoing behavioral testing. Values are expressed as mean±SEM. (n=6–8 per group) of AEA (pmol/g) or 2-AG (nmol/g) concentrations. *p<0.05 compared with saline-treated rats; #p<0.05 compared with URB597 vehicle (V) controls; +p<0.05 compared with saline-treated vehicle (V) controls.