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. Author manuscript; available in PMC: 2014 May 16.
Published in final edited form as: Nature. 2013 May 1;497(7449):383–387. doi: 10.1038/nature12080

Figure 4. p-Y393-AGO2 enhances cell survival and invasiveness under hypoxia and correlates with poorer overall survival in breast cancer patients.

Figure 4

a, Cell apoptosis analysed by FACS (n = 3). b, In vitro migration assay. Result was calculated on the basis of five randomly selected fields per membrane in triplicate (n = 3). c, In vitro three-dimensional invasion assay (n = 5). d, Representative images of immunohistochemical staining of p-Y393-AGO2 in human breast tumour and its adjacent normal tissue. e, Correlation between p-Y393-AGO2 and overall survival in breast cancer patients (n = 125). P <0.0001, Kaplan–Meier survival analysis. All data represent mean ± s.d.; *P <0.05, t-test.