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. Author manuscript; available in PMC: 2013 Jul 22.
Published in final edited form as: Endocr Relat Cancer. 2012 Jan 9;19(1):29–38. doi: 10.1530/ERC-11-0155

Figure 1.

Figure 1

Individual agent-signaling inhibition. (Panel A) TT cells were treated with 0.1 and 0.5 µM of sorafenib for 1, 3, and 6 h. Sorafenib inhibits phosphorylation of Ret, Erk, and p70S6 kinase. Akt inhibition was incomplete in the TT cell line and did not correlate with loss of cell number. (Panel B) MZ CRC1 cells were treated with sorafenib at the same doses and times as for TT cells. In both the cell lines, 0.1 µM sorafenib inhibits pErk at 1 h and then the inhibition is lost, while the other pathways remain suppressed. Everolimus selectively inhibits p70S6K phosphorylation and induces an increase in both Ret and Akt phosphorylations in both the cell lines. (Panel C) AZD6244 selectively inhibits Erk phosphorylation. There is a modest induction of Akt phosphorylation that is noted.