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Everolimus-induced Akt activation, but not Ret activation, is dependent on the mTORC2 complex. MZ-CRC-1 cells were transfected with control (scrambled) and Rictor siRNAs. Rictor SiRNA reduced Rictor levels by ~50%. Everolimus-induced Akt phosphorylation was partially inhibited while the level of phospho-Ret was unaffected by Rictor siRNA.
