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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Pediatr Crit Care Med. 2013 Feb;14(2):194–202. doi: 10.1097/PCC.0b013e31825bbbc2

Table 2.

Final PPK Model and Population Parameter Estimates 509 from original data and bootstrap parameter estimates obtained from bootstrap procedure

Original Data Set 1000 Bootstrap Replicates
Estimate SE Mean 95% CI
Structural Model
 CL (L/hr)
 Vc (L)		 0.672
64.9		 0.177
2.05		 0.665
64.7		 0.388, 0.958
58.3, 72.2
Inter-individual Variability
 ω2CL
 ω2Vc		 0.175
-		 0.0616
-		 0.180
-		 0.0175, 0.469
-
Covariate Model
 WT Effect on CL
 PNAc50 on CL
 WT Effect on Vc		 0.75 (Fixed)
22.1
1.0 (Fixed)		 -
8.50
-		 -
21.6
-		 -
8.61, 36.5
-
Residual Variability
 Proportional error σprop,
 Additive error		 0.197
6.12		 0.0194
0.830		 0.187
5.60		 0.101, 0.258
1.19, 7.61

SE = standard error of estimates

CL = clearance

Vc = volume of distribution

WT = body weight

ω2CL = interindividual variance of CL

ω2Vc = interindividual variance of Vc

PNAc50 = the postnatal age value at which clearance reaches half its maximal value.

CI = confidence interval.