Table 1.

Statistical analysis of the fit of dose–response curve (Figure 1) (A) PLC = min_PLC + (max_PLC - min_PLC)/[1 + (C/EC₅₀)^slope)] to PLC and (B) pixel brightness (pb) from MRI {pb = min_pb + (max_pb - min_pb)/[1 + (C/EC₅₀)^slope]}.

A. PLC method
R = 0.96802847	R2 = 0.93707912	Adjusted R2 = 0.92849900
Parameter estimates
	Coefficient	SE	t	P
min	8.3246	3.3956	2.4516	0.0226
max	100.0000	13.9177	7.1851	<0.0001
EC50	2.5167	0.3125	8.0525	<0.0001
Hillslope	-2.9890	1.0380	-2.8795	0.0087
Analysis of variance:
	DF	SS	MS	F	P
Regression	3	25308.9213	8436.3071	109.2152	<0.0001
Residual	22	1699.3865	77.2448
Total	25	27008.3078	1080.3323
B. MRI - Pixel brightness
R = 0.90873197	R2 = 0.82579380	Adjusted R2 = 0.79505153
Parameter estimates
	Coefficient	SE	t	P
Minimum	1262.0805	945.4022	1.3350	0.1995
Maximum	10171.8589	908.9276	11.1911	<0.0001
EC50	2.7009	0.2490	10.8459	<0.0001
Hillslope	6.2416	2.8575	2.1843	0.0432
Analysis of variance:
	DF	SS	MS	F	P
Regression	3	270109225.7591	90036408.5864	26.8618	<0.0001
Residual	17	56981175.6885	3351833.8640
Total	20	327090401.4476	16354520.0724