Figure 4.

Normal left-sided heart function in Prkg1^−/− mice. A: Transthoracic M-mode echocardiographic tracings in a WT and Prkg1^−/− mouse (45-day-old littermate). Double-sided arrows, LV dimensions. EDD, end-diastolic dimension; ESD, end-systolic dimension; FS, fraction shortening, indicating cardiac contractility. B: Histological sections of hearts from 45-day-old littermates. Hearts were fixed in formalin and stained with H&E. Data are representative of three independent experiments with nearly identical results. C: Measurement of carotid artery pressure demonstrating no systemic hypertension in Prkg1^−/− mice. Data are expressed as mean ± SD (n = 3). *P > 0.05. CADP, carotid artery diastolic pressure; CASP, carotid artery systolic pressure; KO, knockout.