Table 5. Clusters of MMTV CIS genes1.
| Chromosome 7 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Distance (bp) | 18,398 bp | 31,289 bp | ||||||
| Tumor ID | Fgf3 | Fgf4 | Fgf15 | |||||
| 3369 | I | N | Y | Y | ||||
| 3430 | I | N | N | Y | ||||
| 3955 | I | Y | N | Y | ||||
| 3997 | N | I | N | Y | ||||
| 4114 | N | I | Y | Y | ||||
| 4342 | I | N | N | Y | ||||
| 5262 | Y | N | I | Y | ||||
| 5294 | Y | Y | I | Y | ||||
| 5447 | I | N | Y | Y | ||||
| 6305 | N | I | N | Y | ||||
| 6463 | N | I | N | Y | ||||
| Chromosome 15 | ||||||||
| Distance(bp) | 34,139 bp | 18,095 bp | 13,920 bp | |||||
| Tumor Id | Arf3 | Wnt10b | Wnt1 | Ddn | ||||
| 3997 | N | N | N | Y | ||||
| 4114 | N | N | I | N | Y | |||
| 4387 | N I | N | Y | Y | ||||
| 4533 | N | N | Y 2 I | N | ||||
| 6638 | N I | Y | Y | Y | ||||
| 7454 | N | N | I | Y | Y | |||
| 4342 | N | N | Y I | Y | ||||
| 4354 | N | Y | Y I | Y | ||||
| 4443 | N | Y | I | Y | Y | |||
| 4475 | N | N | I | N | Y | |||
| 6385 | Y | Y | I | Y | Y | |||
| Chromosome 19 | ||||||||
| Distance(bp) | 12,745 bp | |||||||
| Tumor ID | Fgf8 | Npm3 | ||||||
| 6638 | I | Y | Y | |||||
| 6305 | I | Y | Y | |||||
| 8000 | I | Y | N | |||||
| 4485 | I | Y | Y | |||||
| 3430 | I | Y | N | |||||
| 3369 | I | Y | Y | |||||
| 4143 | I | Y | Y | |||||
1
Three examples of the effect of MMTV integration on the expression of clusters of genes. The distance between the genes is indicated in base pairs. Genes that are expressed are indicated with “Y” and those not expressed with “N”. “I” indicates the region of the cluster in which MMTV integrated ie. 5'of Fgf3, in between Fgf3 and Fgf4 or Fgf4 and Fgf15. In some tumors the virus integrated within Wnt1.