Table 7. CIS gene orthologues in human tumors¹.

Mouse or Virus Strain	Gene ID	Human Gene Symbol	Gene Ranker Score	Rank out of 7658	Broad	Cosmic	Vogelstein	Sanger
MMTVSP	2268	FGR	1.25	2587	Y
Core	5156	PDGFRA	11	11	Y	Y	Y	Y
Core	2248	FGF3	1.25	2585
Core	2249	FGF4	1.25	2586
MMTVSP	2E+05	PHACTR1	1.5	2319	Y
MMTVCZ & SP	6383	SDC2	2	1741
Core	3E+05	RSPO2	1.5	2383		Y
Core	7480	WNT10B	2.5	980		Y
Core	7471	WNT1	1.25	2829	Y
MMTVCZ & SP	4855	NOTCH4	2.75	740	Y
Core	2253	FGF8	1.5	2141

¹The human orthologues of MMTV CIS genes that are at risk of mutation in human cancers as determined by The Cancer Gene Atlas (TCGA) [28, 29]. TCGA is comprised of 39 gene lists containing a total of 7658 genes which have been ranked in part by the number of gene lists on which they appear. Each list that is contributed to Gene Ranker gets a score: [38] and a ranking out of the 7658 genes in the TCGA catalogue. A ranking of less than 3500 is associated with a gene that is at “high risk” for mutation in human cancer. A “Y” indicates that mutations have been found in that particular gene in the Cosmic [30], Sanger [31], Broad 2000 [29] and/or Volgestein/Kinzler [32] databases of mutations identified by nucleotide sequence analysis. The particular mouse or virus strain with which the gene was identified is indicated.