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Low-dose leptin administration normalizes lipid levels in STZ-diabetic mice. The 4-h fasted plasma triglycerides (A), FFA (B), and β-hydroxybutyrate (C) were measured in mice transplanted with islets with or without leptin and in untreated diabetic (sham-vehicle) mice, leptin-treated diabetic (sham-leptin) mice, and nondiabetic controls on day 12 after surgery. Data are presented as mean ± SEM (n = 3–5). *P < 0.05. †P < 0.05 vs. nondiabetic controls. ‡P < 0.05 vs. STZ-vehicle controls.
