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. 2013 Jul 17;62(8):2978–2983. doi: 10.2337/db12-1627

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© 2013 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 2. — Graphic representation of effects of genetic variants on the relationship between glucose and insulin levels during OGTT in nondiabetic participants of the PPP-Botnia Study. Effect sizes are betas from linear regression adjusted for age, sex, and BMI. KCNQ1† represents rs2237895, and KCNQ1* represents rs231362. Black circles, P < 0.05; white circles, P > 0.05. A: The relationship between fasting insulin and fasting glucose. MTNR1B showed the highest effect on fasting glucose despite elevated insulin levels. CHCHD2P9 showed increased whereas FADS1 showed decreased fasting insulin. B: The relationship between 2-h insulin and 2-h glucose. GCK, CDKAL1, ZBED3, and MTNR1B all showed high postprandial glucose levels despite elevated insulin levels.