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. 2013 Jul 17;62(8):2978–2983. doi: 10.2337/db12-1627

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© 2013 by the American Diabetes Association.

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FIG. 3. — Graphic representation of effects of genetic variants on the relationship between glucose and glucagon levels during OGTT in nondiabetic participants of the PPP-Botnia Study. Effect sizes are betas from linear regression adjusted for age, sex, and BMI. KCNQ1† represents rs2237895, and KCNQ1* represents rs231362. Black circles, P < 0.05; white circles, P > 0.05. A: The relationship between fasting glucagon and fasting glucose. The highest fasting glucose level related to glucagon level was seen for MTNR1B. IGF2BP2 and CRY2 showed reduced glucagon secretion, whereas BCL11A and HHEX were associated with increased fasting glucagon. B: The relationship between 2-h glucagon and 2-h glucose. ZBED3, IGF1, and NOTCH2 showed elevated whereas KCNJ11 showed decreased postprandial glucagon secretion.