Table 2. Validated sequencing results for 32 LGGs showing mutations in IDH1, ATRX, and TP53.1p/19q status, astrocytoma transcriptional subclass [21], and ALT FISH results are also shown along with patient age, primary/recurrent tumor status, and pathological diagnosis. WT: wild type, A: astrocytoma, O: oligodendroglioma, OA: oligoastrocytoma, II: WHO grade II, III: WHO grade III, NB: neuroblastic, EPL: early progenitor-like, PG: preglioblastoma.
Tumor | Age | Primary/Recurrent | IDH1 | ATRX | TP53 | Pathology | 1p/19q | Astro Subclass | ALT FISH |
---|---|---|---|---|---|---|---|---|---|
G1 | 56 | Primary | p. R132H | WT | p.R141C | A II | intact | NB | NEG |
G2 | 27 | Recurrent | p. R132H | WT | WT | OA II | intact | NB | NEG |
G3 | 41 | Primary | p. R132H | WT | p.P90fs | OA II | intact | NB | POS |
G4 | 31 | Primary | p. R132H | WT | WT | A II | intact | NB | NEG |
G5 | 34 | Primary | p. R132G | p.K1001fs | p.R141C | A II | intact | EPL | POS |
G6 | 40 | Primary | p. R132H | p.L639fs | p.R141C | A II | intact | EPL | POS |
G7 | 35 | Primary | p. R132H | p.E991fs | p.G196A | A II | intact | EPL | POS |
G8 | 38 | Primary | p. R132H | p.R907X | p.R141C | OA II | intact | EPL | POS |
G9 | 41 | Primary | p. R132H | p.1338_1339del | WT | A II | intact | EPL | NEG |
G10 | 29 | Primary | p. R132C | p.1346_1347del | WT | OA II | intact | EPL | POS |
G11 | 58 | Recurrent | p. R132H | p.E1010fs | WT | OA II | intact | EPL | POS |
G12 | 38 | Recurrent | p. R132H | WT | p.L232R | A III | intact | EPL | NEG |
G13 | 43 | Recurrent | p. R132H | p.199_205del | p.R141C | A II | intact | EPL | POS |
G14 | 52 | Primary | p. R132H | p.K1018fs | p.R141C | A III | intact | EPL | POS |
G15 | 36 | Primary | p. R132H | p.R1302fs | p.101_103del | A III | intact | EPL | POS |
G16 | 34 | Primary | p. R132H | p.R221K | p.G196X | A III | intact | EPL | POS |
G17 | 36 | Primary | WT | WT | WT | A III | intact | EPL | NEG |
G18 | 32 | Primary | p. R132H | p.R1426X | WT | OA II | intact | PG | POS |
G19 | 62 | Primary | WT | WT | WT | A II | intact | PG | NEG |
G20 | 65 | Primary | WT | WT | WT | O III | intact | PG | NEG |
G21 | 34 | Recurrent | p.R132H | WT | WT | OA II | codeleted | N/A | NEG |
G22 | 41 | Recurrent | p.R132H | WT | WT | O II | codeleted | N/A | N/A |
G23 | 38 | Primary | p.R132H | WT | WT | O II | codeleted | N/A | NEG |
G24 | 37 | Primary | p.R132H | WT | WT | O III | codeleted | N/A | NEG |
G25 | 52 | Recurrent | p.R132H | WT | WT | O II | codeleted | N/A | NEG |
G26 | 34 | Recurrent | p.R132H | WT | WT | O II | codeleted | N/A | NEG |
G27 | 45 | Primary | p.R132H | WT | WT | O II | codeleted | N/A | NEG |
G28 | 37 | Primary | p.R132H | WT | WT | O II | codeleted | N/A | NEG |
G29 | 62 | Primary | p.R132H | WT | WT | O III | codeleted | N/A | NEG |
G30 | 46 | Primary | p.R132H | WT | WT | O III | codeleted | N/A | NEG |
G31 | 35 | Recurrent | p.R132H | WT | WT | O III | codeleted | N/A | NEG |
G32 | 58 | Primary | WT | WT | WT | O III | codeleted | N/A | NEG |