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. 2012 Sep 28;3(10):1158–1168. doi: 10.18632/oncotarget.557

Figure 5. Effects of HSP90 inhibition with 17-AAG.

Figure 5

The viability of bone marrow MNC from RAEB patients (n=39) was studied after exposure to 2μM or 5μM of 17-AAG for 12 to 24 hours (top left). Apoptosis of the cells was assessed by activated caspase-3 expression and annexin V binding after exposure to 2μM or 5μM of 17-AAG for 24 hours and 12 hours respectively (bottom left). The levels of HSP90, HSP70, pAKT, FAK and pFAK expression was evaluated in MNC (top right) and CD34+ cells (bottom right) after exposure to 2μM or 5μM of 17-AAG for 12 hours.