Figure 1. This model represents the action of AKT on PAX3-FKHR activity in ARMS and terminal muscle differentiation.

PAX3-FKHR plays a dynamic role in ARMS oncogenesis and terminal differentiation block. Enhanced AKT activation inhibits PAX3-FKHR activity and entails for terminal differentiation. Elevating AKT activity by specific small molecule AKT activators may be exploited to inactivate PAX3-FKHR, leading to foil ARMS.