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. Author manuscript; available in PMC: 2013 Jul 22.
Published in final edited form as: Cell. 2013 Jan 17;152(0):340–351. doi: 10.1016/j.cell.2012.12.010

Figure 4. p16LUC Activity Detects Spontaneous Cancers In Vivo.

Figure 4

(A) (Top) Detection of a spontaneous histiocytic malignancy in a 110-week-old p16+/LUC mouse. All luminescent images shown were 1 min in length except the ventral image, which was 2 min long. Organ images were taken immediately following imaging. (Bottom) Haematoxylin and eosin stained fixed tissues confirm the presence of malignancy within luciferase positive regions of the brain and liver.

(B) (Top) Luminescent detection of a spontaneous, disseminated lung adenocarcinoma in a 78-week-old p16+/LUC mouse. Images were generated as in (A) with confirmatory histology shown below.

See also Figure S4 and Table S1.