TABLE III.
IPA-defined pathways enriched for genes with differential expression by race
| Ingenuity canonical pathwaya | −log10P value | Molecules |
|---|---|---|
| PI3K/AKT signaling | 4.27 | JAK1, GYS1, PPP2R4, SOS1, YWHAZ, ITGA5, IKBKE, NFKB2, MAPK7, NFKBIB, CTNNB1, ITGA4 |
| Role of PKR in interferon induction and antiviral response | 4.05 | TRAF2, TRAF3, TNFRSF1A, IKBKE, NFKB2, CASP8, NFKBIB |
| Apoptosis signaling | 4.00 | ENDOG, TNFRSF1A, IKBKE, NFKB2, MAPK7, CAPN7, RPS6KA1, CASP8, NFKBIB, CAPN3 |
| Role of RIG1-like receptors in antiviral innate immunity | 3.84 | DHX58, TRAF2, TRAF3, IKBKE, NFKB2, CASP8, NFKBIB |
| CD40 signaling | 3.63 | TRAF2, TRAF3, CD40, IKBKE, NFKB2, MAPK7, NFKBIB, MAP2K5 |
| Death receptor signaling | 3.02 | DAXX, TRAF2, TNFRSF1A, IKBKE, NFKB2, CASP8, NFKBIB |
| Induction of apoptosis by HIV1 | 2.98 | DAXX, TRAF2, TNFRSF1A, IKBKE, NFKB2, CASP8, NFKBIB |
| 4-1BB signaling in Tlymphocytes | 2.93 | TRAF2, IKBKE, NFKB2, MAPK7, NFKBIB |
| FAK signaling | 2.70 | PAK4, SOS1, ITGA5, MAPK7, CAPN7, ITGA4, CAPN3, GIT2 |
| CD27 signaling in lymphocytes | 2.65 | TRAF2, IKBKE, NFKB2, CASP8, NFKBIB, MAP2K5 |
a
Top 10 ingenuity pathways are shown.