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A, the effects of increased serum bicarbonate concentration on pHe gradient in tumors with 100-fold increase in glucose metabolism. B, the dependency of pHe gradient on the diffusion rate of a hypothetical buffer added to serum. C, the pHe gradient produced by a hypothetical non–CO2-producing buffer compared with bicarbonate confirms that no noticeable difference exists if the other chemical properties (i.e., pK) are kept equal for the two buffers.
