TABLE 1.

Mean dose, rescue medication dose, treatment preference, treatment effectiveness and Global Impression of Change scores

	CR oxycodone/CR naloxone	Placebo	P
Medication dose every 12 h, mg	36.5±7.3/18.2±3.7	38.1±5.5/19.1±2.8	0.1050
Rescue dose, number of acetaminophen/codeine 300 mg/30 mg tablets/day (total administered acetaminophen/codeine, mg)	2.6±3.1 (780/78)	4.3±3.5 (1290/129)	0.0003
Treatment effectiveness*
Patient	1.4±1.0	0.9±1.0	0.0216
Investigator	1.4±1.0	1.0±1.0	0.0258
Treatment preference, %
Patient (20% no preference)	56	24	0.0127
Investigator (15% no preference)	57	28	0.0218
Global Impression of Change scores†
Patient	3.2±1.4	3.9±1.5	0.0102
Investigator	3.1±1.4	4.0±1.6	0.0035

Data presented as mean ± SD unless otherwise indicated.

^*4-point scale: 0 = not effective; 1 = slightly effective; 2 = moderately effective; 3 = highly effective;

^†7-point scale: 1 = very much improved to 7 = very much worse