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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Cancer J. 2013 May-Jun;19(3):238–246. doi: 10.1097/PPO.0b013e31829a68eb

Figure 2. The Anaplastic Lymphoma Kinase (ALK) signaling pathway.

Figure 2

The downstream signaling pathways include the Rat sarcoma (Ras), mitogen activated protein (MAP), extracellular signal regulated kinase (ERK), phosphoinositide 3-kinase (PI3K), Akt, Janus activated kinase (JAK3) and Signal Transducer and Activator of Transcription (STAT3) signaling pathways. In general, the RAS/MEK/ERK pathway drives cell proliferation, and the PI3K/Akt and JAK3-STAT3 pathways play pro-survival roles. Although different ALK fusions may differentially activate downstream signaling pathways, EML4-ALK signals through ERK and PI3K. Activation of the RAS/MEK/ERK and PI3K/Akt pathways play key roles in EML4-ALK–mediated cellular oncogenesis.