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The molecular targets of MLL in hematopoietic stem and progenitor cells. Five transcription factors were identified to be directly regulated by MLL in hematopoietic stem and progenitor cells. The gene activation of Hoxa9 and Mecom is dependent on the MLL cofactor Menin, whereas Eya1, Pbx1, and Prdm16 are cofactor independent. MLL controls HSC maintenance and proliferation through Prdm16 by regulating cell cycle.
