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. 2013 Jul 1;110(29):12048–12053. doi: 10.1073/pnas.1304718110

Fig. 2.

Fig. 2.

PHT and exosomal C19MC miRNAs confer viral resistance to recipient cells. (A) U2OS cells stably expressing control or C19MC BAC were infected with VSV (infection levels assessed by qRT-PCR; *P < 0.0001). (B) U2OS cells were transfected with C19MC miRNA mimics that represent the miRNA subgroups detailed in Table S2 or control mimics and then infected with VSV (shown as percent infected cells assessed by IF; *P < 0.05, **P < 0.001). (C) U2OS cells, transfected with mimics of the six highest expressed C19MC miRNAs, scrambled control, or non-C19MC (miR-1, -424, -630, -720) miRNA mimics, were infected with VSV (infection level assessed by IF or qRT-PCR; *P < 0.0005). (D) U2OS cells, transfected with mimics of the top three antiviral C19MC miRNAs or with scrambled control mimics, were infected with VSV (infection assessed by qRT-PCR; *P < 0.05, **P < 0.0001). (E) U2OS cells, transfected with scrambled control or miR-517b mimic, were infected with VV or HSV-1 (infection assessed as in D; *P < 0.0001).