Fig. 1.

Recovered waves in mice lacking cholinergic waves are modulated by light. (A and B) MEA recordings from a WT P5 (A) and β2KO P5 (B) retina. (Top) Activity pattern corresponding to boxed region in Middle. Each dot represents an electrode site, and the radius of the dot is proportional to the single unit firing rate recorded at that site. Frames correspond to 2 s. (Middle) Raster plot of spike trains of all single units. (Bottom) Average firing rate of all units. (C) Summary data of wave frequency in dark and light for WT, β2KO, and β2-Opn4 dKO mice. Open circles correspond to individual retinas and recordings from the same retinas are connected by dotted lines. (D) Summary data of burst duration during a wave in dark and light for WT, β2KO, and β2-Opn4 dKO mice. Error bars in C and D correspond to SEM. *P < 0.05; ***P < 0.001, paired t test.