Fig. 3.

ipRGCs do not function as hub neurons for retinal waves. (A) Correlation index versus interelectrode distance for pairs of spike trains for WT (black) and β2KO (blue) mice, in the light. Data points correspond to averages of median values from individual retinas and error bars correspond to SEM. (B and C) Connectivity maps of WT P5 (B) and β2KO P5 (C) in the light. Circles correspond to location of single units with diameter scaled by the magnitude of the normalized correlation index. Red circles correspond to units that were connected to at least 15% of other units, and blue lines show their connections. Turquoise circles correspond to units identified as ipRGCs. (D) Cumulative probability distributions of the distances of connections from highly connected cells for WT (black) and β2KO (blue) retinas in the dark and light. (E) Percent of ipRGCs that are highly connected hub neurons for WT (gray) and β2KO (blue) activity, in dark and light. Box plots range from lower to upper quartiles (25% and 75%) with median values indicated by central black line; whiskers (dotted lines) range from 5% to 95%. Faded box plots correspond to percentage of ipRGCs that are highly connected that we would expect from chance. **P < 0.01, Wilcoxon rank sum test.