Fig. 4.

In vivo levels of IL-12 and IFN-γ after virus treatment. (A) Schema for experiment. Tumor-bearing mice were killed on days 1 and 6 posttreatment and tumor and serum isolated. (B) ELISA for mouse IL12p70 in tumor homogenates, showing a significant increase only after G47∆-mIL12 treatment (day 1; *P < 0.05 versus PBS or G47∆-E). (C) Tumor IFN-γ (ELISA) was significantly increased only after G47Δ-mIL12 treatment on days 1 and 6 (*P < 0.05 versus PBS). (D) Serum IFN-γ was increased on day 1 after G47Δ-mIL12 treatment (P < 0.05; paired t test). Error bars indicate SEM.