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MudJ transposon insertions in mdtABCD baeSR confer streptonigrin sensitivity. A screen for S. Typhimurium mutants with enhanced SN sensitivity identified three independent insertions in mdtB. The mdtABCD baeSR operon encodes an RND-family efflux pump (MdtABC) that forms a complex with TolC to efflux substrates, an uncharacterized MFS pump (MdtD/IceT), and a two-component regulatory system (BaeSR).
