Fig. 1.

Models for transcript exit in rotavirus. (A) Channel specialization model: each RNA exit channel is linked to a specific TC and transcripts (thin blue and red lines for segments x and y, respectively) of a single specific genomic segment (thick blue and red lines for segments x and y, respectively). This model predicts that only a single transcript of each viral genomic segment is extruded from each DLP at any given time. (B) Channel generality model: a segment can interact with multiple TCs and their corresponding RNA exit channels during transcription. This model predicts that multiple transcripts from each genomic segment can be extruded from each DLP at any given time.