Figure 2. PMO delivery by the combination of Bubble liposomes and ultrasound.

1–25 PMO (20 μg) or saline was locally administrated into TA muscles of HSA^LR mice with/without Bubble liposomes (BLs) and ultrasound (US). The inclusion rate of exon 7A decreased most when both Bubble liposomes and ultrasound were applied. (n = 3). The bars indicate mean and s.e.m., and statistical significance was analysed by Tukey's multi-comparison test (* P < 0.05, ** P < 0.01).