Fig. 5.
Vaccine-induced antibody-dependent cell-mediated cytotoxicity responses to SIVmac251gp120. CD3−CD20−CD56+ human PBMCs (NK cells) were incubated with SIVmac251gp120-coated CEM-NKr-CCR5 target cells and plasma sampled from the monkeys on the day of challenge. The expression of CD107a, IFNγ, TNF-α, and MIP-1β by the NK cells was evaluated by intracellular cytokine staining. Data are expressed as percentage of NK cells expressing these molecules. No statistically significant differences between the magnitudes of the responses in these groups in each study were noted as determined by the Mann-Whitney test.