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. Author manuscript; available in PMC: 2013 Jul 22.
Published in final edited form as: Nat Immunol. 2012 Aug 26;13(10):947–953. doi: 10.1038/ni.2403

Figure 2. LTβR influences weight gain through changes in the microbiota.

Figure 2

(a) Food consumed represents the weight difference of food between n and n+1 days of a given cage of mice over the course of the first two weeks on diet (b–c) Germ free mice were gavaged with cecal contents from Ltbr+/− or Ltbr−/− littermates maintained on NCD or HFD for 9–10 weeks starting at 9 weeks of age. Cecal contents from two donors was pooled. Recipients were kept on diets of similar compositions to donors. (b–c) Weight gain as a percentage of starting body weight is shown 20 days after gavage of germ free recipients from the NCD (b) and HFD (c) groups. (D) RT-PCR for SFB on DNA from stool collected from Ltbr+/− and Ltbr−/− mice 4 weeks after NCD start (n=4 mice per group, representative of 3 independent experiments for a and d; n=3–5 germ free mice/group, representative of 2 independent experiments Summary of p-values: * P <0.05, ** P <0.001, student’s t test for a and d, paired-t test for b and c)