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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Pediatr Neurol. 2013 Aug;49(2):107–112. doi: 10.1016/j.pediatrneurol.2013.03.015

Table 2.

Callosal Measures Correlate with Development and Sterols in SLOS (N = 36).

Length (mm) Area (mm2)
r p-value r p-value
GMDQ 0.46 <0.01 0.50 <0.01
LDQ 0.37 0.03 0.37 0.03
FMADQ 0.18 0.32 0.17 0.33
SS −0.28 0.10 −0.32 0.06
7DHC (initial) −0.54 <0.01 −0.53 <0.01
7DHC (at MRI) −0.52 <0.01 −0.65 <0.01
8DHC (at MRI) −0.52 <0.01 −0.56 <0.01
CHL (initial) 0.58 <0.01 0.55 <0.01
CHL (at MRI) 0.43 0.01 0.51 <0.01
Ratio (at MRI) −0.45 0.01 −0.59 <0.01

Developmental quotients for gross motor (GMDQ), language (LDQ), and fine motor/adaptive skills (FMADQ) domains were calculated as DQ = (developmental age/chronologic age) × 100. SLOS anatomic severity scale score (SS); 7-dehydrocholesterol. mg/dL (7DHC); 8-dehydrocholesterol, mg/dL (8DHC); Total cholesterol, mg/dL (CHL); Ratio = (7DHC + 8DHC) / (7DHC + 8DHC + CHL). Initial sterol level was obtained at time of diagnosis, and sterol level at MRI was obtained at time of scan. We considered p < 0.05 for Pearson's correlation (r) to be significant.