Table 3. Risk factors for progression to ALI.
| Factor | Progression to ALI (n=61) |
No progression to ALI (n=74) |
P |
|---|---|---|---|
| Baseline characteristics | |||
| Age (yrs) | 62.4 (±15.6) | 63.1 (±17.4) | 0.82 |
| Male, n (%) | 30 (49.2) | 45 (60.8) | 0.18 |
| Comorbidities, n (%) | |||
| Diabetes | 21 (34.4) | 22 (29.7) | 0.55 |
| Cirrhosis | 3 (4.9) | 2 (2.7) | 0.66 |
| Malignancy | 15 (24.6) | 16 (21.6) | 0.68 |
| COPD | 11 (18.0) | 10 (13.5) | 0.47 |
| Height (in) | 66.8 (±4.0) | 66.8 (±3.3) | 0.96 |
| Weight (kg) | 80.6 (60.0-93.2) | 69.7 (57.2-81.8) | 0.02 |
| IBW (kg) | 63.4 (±11.1) | 63.9 (±9.1) | 0.79 |
| BMI | 27.5 (22.7-32.3) | 23.9 (20.4-28.7) | 0.006 |
| Lactate | 3.8 (2.3-6.4) | 3.1 (1.8-5.1) | 0.44 |
| APACHE II | 24.0 (±5.9) | 21.8 (±5.9) | 0.03 |
| SOFA | 9.0 (±3.3) | 7.3 (±3.8) | 0.01 |
| CVP | 12.3 (±5.1) | 10.4 (±4.5) | 0.10 |
| ScvO2 | 77.0 (68.0-84.0) | 78.0 (69.0-84.0) | 0.88 |
| ED LOS | 5.5 (4.3-7.0) | 4.9 (3.9-7.1) | 0.46 |
|
| |||
| Process of Care Variables | |||
|
| |||
| Time to antibiotic administration (hours) |
1.7 (1.2-2.8) | 2.0 (1.3-2.8) | 0.64 |
| Fluids over first 6 hours (liters) | 3.3 (2.0-4.0) | 4.0 (2.0-5.0) | 0.34 |
| Vasopressor use, n (%) | 50 (82.0) | 46 (62.2) | 0.01 |
| Blood product administration, n (%) |
3 (4.9) | 9 (12.2) | 0.14 |
| ScvO2 ≥ monitored, n (%) | 31 (50.8) | 49 (66.2) | 0.37 |
| ScvO2 ≥ 70% achieved, n (%) | 22 (36.1) | 25 (33.8) | 0.97 |
|
| |||
| Ventilator Variables | |||
|
| |||
| Ventilator mode VC-AC, n (%) |
56 (91.8) | 72 (97.3) | 0.12 |
| PEEP | 5.0 (5.0-5.0) | 5.0 (5.0-5.0) | 0.85 |
| FiO2 | 100.0 (100.0-100.0) | 100.0 (100.0-100.0) | 0.18 |
| Tidal volume, mL/kg IBW | 8.6 (7.7-9.7) | 8.8 (7.7-9.6) | 0.83 |
| Lung-protective ventilation, n (%) |
18 (29.5) | 24 (33.3) | 0.63 |
| Peak pressure, cmH2O | 29.0 (23.0-36.0) | 28.0 (25.0-33.0) | 0.74 |
| Mean pressure, cmH2O | 10.0 (9.0-12.0) | 9.0 (8.0-11.0) | 0.11 |
| Plateau pressure, cmH2O | 23.0 (16.0-27.0) | 17.5 (15.0-24.0) | 0.24 |
CHF = congestive heart failure; COPD = chronic obstructive pulmonary disease; IBW = ideal body weight; BMI = body mass index; APACHE = Acute Physiology and Chronic Health Evaluation; SOFA = Sequential Organ Failure Assessment Score; CVP = central venous pressure; ScvO2 = central venous oxygen saturation; LOS = length of stay; VC = volume controlled; AC = assist control; PEEP = positive end expiratory pressure; FiO2 = fraction of inspired oxygen
Continuous variables are reported as mean (± standard deviation) and median (interquartile range) unless otherwise noted.