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Caspr2 interaction with juxtaparanodal proteins. Caspr2 is an axonal protein that binds contactin-2 in cis and trans orientations to organize the juxtaparanodal region. Caspr2 links to PDZ-binding proteins, and to the cytoskeleton via protein 4.1B. Caspr2 organizes Kv1 potassium channels in the juxtaparanodal region, although the underlying mechanism remains to be determined. Abbreviation: Caspr2, contactin-associated protein-like 2.
