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Study selection. t, number of trials; a, number of arms; n, number of treated patients; BSC, best supportive care; 5-FU, 5-fluorouracil; Gem, gemcitabine. In the trial by Conroy et al., patients were randomized to two arms FOLFIRINOX or gemcitabine then received a second-line of gemcitabine if they progressed on FOLFIRINOX* or 5-FU-based regimen if they progressed on gemcitabine**.
