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Strategy for the discovery and development of SBiXs. An iterative process that includes computer-aided drug design (CADD), high-throughput screening (HTS), structure/activity (SAR) and medicinal chemistry, 3D structure (NMR and X-ray), and a specificity filter is used to engineer modified SBiXs for intratumoral in vivo screening and subsequent advanced leads suitable for preclinical evaluation.
