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Examples of investigational transferrin-fusion proteins
| Name | Effector protein | Impact on PK | Targets | Disease | Proposed mechanisms of action | Reference |
|---|---|---|---|---|---|---|
| GH-Tf | Growth hormone (GH) | Prolong half-life | GH receptor | GH deficiency | GH receptor agonist | 51 |
| G-CSF-Tf | Granulocyte colony stimulating factor (G-CSF) | Prolong half-life | G-CSF receptor | Neutropenia | G-CSF receptor agonist | 51 |
| GLP-1-Tf | Glucagon-like peptide-1 (GLP-1) | Prolong half-life | GLP-1 receptor | Type 2 diabetes mellitus | GLP-1 receptor agonist | 38 |
