Table 2.
NCBI accession numbers (number.version) of nucleotide-sugar transporter genes referenced in this study
| Source organism (tree prefix) a | Gene identifier b | Nt accession | Prot. accession | NST Substrate(s) c | References |
|---|---|---|---|---|---|
|
Homo sapiens (Hs) |
SLC35C1 |
NM_018389.4 |
NP_060859.4 |
GDP-L-Fuc |
[21,27,28,54] |
| |
SLC35B4 |
NM_032826.4 |
NP_116215.1 |
UDP-Xyl, UDP-GlcNAc |
[55] |
| |
SLC35A3/hUGlcNAcT |
NM_012243.1 |
NP_036375.1 |
UDP-GlcNAc |
[56] |
| |
SLC35D2/hUGTrel8/HFRC1 |
NM_007001.2 |
NP_008932.2 |
UDP-Glc, UDP-GlcNAc, GDP-Man |
[57] |
| |
hUGTrel7 |
AB044343.1 |
BAB18586.1 |
UDP-GlcA, UDP-GalNAc |
[58] |
| |
hUGT1 |
D84454.1 |
BAA12673.1 |
UDP-Gal, UDP-GalNAc |
[59-62] |
|
Canis lupus (Cl) |
SLC35A3 |
NM_001003385.1 |
NP_001003385.1 |
UDP-GlcNAc |
[63] |
| |
SLC35A2 |
NM_001003059.2 |
NP_001003059.2 |
UDP-Gal |
[64] |
|
Mus musculus (Mm) |
Slc35c1 |
NM_211358.2 |
NP_997597.1 |
GDP-L-Fuc |
[30,65] |
| |
Slc35b4 |
NM_021435.3 |
NP_067410.1 |
UDP-Xyl, UDP-GlcNAc |
[66] |
| |
mUGT1 |
AB027147.1 |
BAA86885.1 |
UDP-Gal |
[67] |
| |
Slc35a1 |
NM_011895.3 |
NP_036025.2 |
CMP-Sia |
[68] |
|
Cricetulus griseus (Cgr) |
Slc35a1 |
NM_001246755.1 |
NM_001246755.1 |
CMP-Sia |
[69] |
|
Drosophila melanogaster (Dm) |
Gfr |
NM_141525.1 |
NP_649782.1 |
GDP-L-Fuc |
[70,71] |
| |
Efr |
NM_132071.1 |
NP_572299.1 |
" " |
[72] |
| |
Frc |
AB062677.1 |
BAB62105.1 |
UDP-GlcA, UDP-GalNAc, UDP-Gal, UDP-GlcNAc, UDP-Xyl |
[73,74] |
| |
ugt |
AB055493.1 |
BAB62747.1 |
UDP-Gal, UDP-GalNAc |
[62,75] |
|
Caenorhabditis elegans (Ce) |
C50F4.14 |
AF323969.1 |
AAK50396.1 |
GDP-L-Fuc |
[28] |
| |
SQV-7 |
NM_063035.4 |
NP_495436.1 |
UDP-GlcA, UDP-GalNAc, UDP-Gal |
[76] |
|
Schistosoma mansoni (Sm) |
GFT |
GU574756.1 |
ADO17519.1 |
GDP-L-Fuc (putative) |
Present study |
|
Leishmania donovani (Ld) |
LPG2 |
U26175.1 |
AAC46914.1 |
GDP-Man, GDP-Ara, GDP-Fuc |
[77] |
|
Cryptococcus neoformans (Cn) |
GMT1 |
XM_571496.1 |
XP_571496.1 |
GDP-Man |
[78] |
| |
GMT2 |
XM_571874.1 |
XP_571874.1 |
" " |
" " |
|
Saccharomyces cerevisiae (Sc) |
YEA4 |
NM_001178819.1 |
NP_010912.1 |
UDP-GlcNAc |
[79] |
|
Candida albicans (Ca) |
VRG4 |
AF164627.1 |
AAK74075.1 |
GDP-Man |
[80] |
|
Candida glabrata (Cgl) |
Vrg4 |
AF360395.1 |
AAK51897.1 |
GDP-Man |
[81] |
|
Arabidopsis thaliana (At) |
GONST1 |
AJ314836.1 |
CAC69066.1 |
GDP-Man |
[82,83] |
| |
GONST2 |
NM_100603.5 |
NP_172209.4 |
" " |
[83] |
| |
AtUTr1 |
AY115566.1 |
AAM48281.1 |
UDP-Gal, UDP-Glc |
[84] |
| |
NST-K1 |
NM_179196.1 |
NP_849527.1 |
UDP-Gal |
[85] |
| |
udpgalt1 |
AJ633720.1 |
CAG18176.1 |
" " |
[86] |
| udpgalt2 | AJ633721.1 | CAG18177.1 | " " | " " |
a “tree prefix” refers to nomenclature applied in phylogenetic analyses of NSTs (Figure 6, in Additional file 3: Figure S2).
b Official gene names/identifiers are provided. Genes in boldface type were used as query sequences to search for GDP-L-fucose transporter homologs in the SchistoDB [35].
c NST activity has been demonstrated for these substrates. GDP-Fuc, GDP-L-fucose; UDP-Xyl, UDP-D-xylose; UDP-GlcNAc, UDP-D-N-acetylglucosamine; UDP-Glc, UDP-D-glucose; UDP-GlcA, UDP-D-glucuronic acid; UDP-GalNAc, UDP-D-N-acetylgalactosamine; UDP-Gal, UDP-D-galactose; GDP-Man, GDP-D-mannose; CMP-Sia, CMP-sialic acid; GDP-Ara, GDP-D-arabinose.