Table 1.

Prognostic clinical features of ALL

Risk factors	Prognosis association
At presentation
Age	Adverse outcome with advancing age
CNS involvement	Adverse outcome
Presenting WBC count	Adverse for B-ALL > 30
	Adverse for T-ALL >100
ECOG PS	Poor PS at diagnosis were an independent predictor of inferior outcomes
Cytogenetics	Favorable: hyperdiploidy
	Adverse: t(9;22), t(4;11), t(8;14), complex (≥ 5 abnormalities), hypodiploidy, triploidy, -7, del(7p), +8, MLL translocations, t(1;19), t(17;19), t(5;14)]
In response to therapy
Time to initial response	Adverse: failure to attain complete remission within 4 weeks of induction
Detection of MRD	Adverse: detection at various time-specific points in several studies