Table 4. Results of the association between medical risk factors and cholangiocarcinoma stratified by sex and age, statistically significant interaction only (p<0.05).
| Intrahepatic cholangiocarcinoma | Extrahepatic cholangiocarcinoma | |||||
| Risk factors | OR (95% CI)a | Interaction P-valuea | ORa (95% CI)a | Interaction P-valuea | ||
| Sex | ||||||
| Male | Female | Male | Female | |||
| Cholangitis | 7.8 (5.3–11.5) | 22.0 (13.6–35.4) | 0.001 | |||
| Cholelithiasis | 4.7 (3.9–5.6) | 9.3 (7.7–11.2) | <0.0001 | 3.8 (3.1–4.7) | 5.8 (4.7–7.1) | 0.005 |
| Hepatitis B | 4.3 (3.2–5.9) | 1.7 (1.1–2.5) | 0.0003 | |||
| Hepatitis C | 3.0 (2.0–4.7) | 1.5 (0.9–2.6) | 0.05 | |||
| Diabetes | 1.6 (1.4–1.8) | 2.1 (1.8–2.5) | 0.01 | |||
| Peptic ulcer | 2.4 (2.2–2.7) | 3.1 (2.7–3.5) | 0.006 | |||
| Age | ||||||
| ≦65 | >65 | ≦65 | >65 | |||
| Cholelithiasis | 5.7 (4.5–7.4) | 4.2 (3.5–5.0) | 0.05 | |||
| Cirrhosis of liver | 11.5 (8.4–15.7) | 6.0 (4.6–7.8) | 0.002 | 6.4 (4.0–10.2) | 2.9 (2.1–4.1) | 0.01 |
a
Odds ratio (OR), 95% confidence interval (CI), and interaction p-values were derived using conditional logistic regression with age, sex, and the time of diagnosis (reference date for the controls) as matching variables.