Table 2. Genotype and allele frequencies of the Fibrinogen Aα Thr312Ala polymorphism.
| Polymorphism | Genotype/allele | Frequency | p value | |||
| CTEPH | PTE | Control | Between 3 groups | Between 2 groups | ||
| Aα Thr312Ala (A/G) rs6050 | A/A | 25%(25/100) | 37%(37/99) | 43%(45/106) | P = 0.034 | CTEPH/control 0.017 |
| A/G | 57%(57/100) | 55%(54/99) | 48%(51/106) | PTE/control 0.654 | ||
| G/G | 18%(18/100) | 8%(8/99) | 9%(10/106) | CTEPH/PTE 0.044 | ||
| A | 55%(109/200) | 64%(128/198) | 67%(141/212) | P = 0.01 | CTEPH/control 0.005 | |
| G | 45%(95/200) | 35%(70/198) | 33%(71/212) | PTE/control 0.691 | ||
| CTEPH/PTE 0.018 | ||||||
All frequencies are presented as % (n/total sample number). Genotype and allele frequencies were analyzed using the Chi-squared test, or Fisher’s exact test in the case of low numbers. CTEPH: chronic thromboembolic pulmonary hypertension; PTE: pulmonary thromboembolism. Thr: threonine; Ala alanine;