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. 2013 Jul 22;8(7):e69455. doi: 10.1371/journal.pone.0069455

Figure 1. Expression of TCSs and ABC transporters in S. aureus exposed to nukacin ISK-1.

Figure 1

Analysis of expression levels of braR, graR, vraR, braA, vraD, and vraF were performed as described in the Materials and Methods. (A) braA, vraF, vraD, braR, graR, and vraR expression in S. aureus MW2 exposed to various concentrations of nukacin ISK-1 (5-min exposure). *, statistically significant difference from the wild-type as tested using Dunnett’s method (p<0.05). (B) Time course experiment of braA, vraF, and vraD expression in S. aureus MW2 exposed to nukacin ISK-1 (4 µg/ml). (C) braA, vraF, and vraD expression in S. aureus MW2 and three mutants (braRS, graRS, and vraSR mutant) exposed to nukacin ISK-1 (4 µg/ml). *, statistically significant difference from the wild-type as tested using Dunnett’s method (p<0.05).