Table 2.
Baseline demographic and clinical parameters
|
Treatment group |
All |
Patients in whom delayed haemolysis could be assessed |
|||
|---|---|---|---|---|---|
| All | All | Quinine (iv) | Quinine (iv) and artesunate (ir) | Artesunate (iv) | |
| n |
36 |
16 |
8 |
4 |
4 |
| Female |
13 (36) |
4 (25) |
2 (25) |
1 (25) |
1 (25) |
| Visiting friends and relatives |
10 (28) |
5 (31) |
3 (38) |
1 (25) |
1 (25) |
| Traveling from sub-Saharan Africa |
35 (97) |
16 (100) |
8 (100) |
4 (100) |
4 (100) |
| ICU treatment |
25 (69) |
12 (75) |
6 (75) |
4 (100) |
2 (50) |
| Deaths |
1 (3) |
0 (0) |
0 (0) |
1 (25) |
0 (0) |
| Hospital stay duration in days, median (IQR) |
10 (7–18) |
17 (9–30) |
19 (11–30) |
17 (4–46) |
11 (6–16) |
| Age in years, median (IQR) |
49 (35–55) |
48 (37–57) |
42 (35–48) |
55 (41–59) |
54 (28–62) |
| Temperature in °C |
38.1 (37.5-38.6) |
38.1 (37.6 – 38.6) |
38.2 (37.4- 39.0) |
37.1 (37.0 – 37.2) |
38.5 (37.6 – 39.4) |
| Parasitaemia in%, median (IQR) |
15 (7–25) |
15 (7–24) |
12 (5–15) |
33 (26–39) |
17 (8,-21) |
| Hb (g/dl, normal range:12.0-16.0 ) |
11.4 (10.2-12.5) |
11.4 (10.0 – 12.9) |
11.9 (9.4-14.3) |
9.8 (6.4-13.1) |
12.3 (7.7-16.9) |
| WBC (1000/μl, normal range: 3.5 – 10.5) |
6.9 (5.4-8.4) |
8.1 (5.3-10.9) |
7.8 (4.6-11.0) |
11.6 (0.0-24.8) |
5.5 (1.1-9.9) |
| Creatinine (mg/dl, normal range: 0.6 – 1.3) |
1.6 (1.0-2.2) |
2.0 (1.3-2.8) |
2.0 (0.7-3.3) |
1.7 (0.0-3.6) |
2.5 (0.6-4.4) |
| Bilirubin (mg/dl, normal range: <1.2) |
4.0 (2.7-5.2) |
5.0 (3.9-6.1) |
4.9 (3.0-6.8) |
4.2 (0.0-10.3) |
5.9 (3.3-8.5) |
| GOT (U/l, normal range: <50) |
115 (71–158) |
153 (102–205) |
149 (46–251) |
163 (21–305) |
153 (55–251) |
| GPT (U/l, normal range: <50) |
75 (52–98) |
84 (57–111) |
77 (40–115) |
65 (8–120) |
116 (4–228) |
| C-Reactive Protein (mg/l, normal range:<5) | 182 (145–219) | 178 (130–226) | 187 (90–284) | 178 (25–331) | 163 (74–225) |
Data are shown as number (%) or mean (with 95% standard deviation), if not indicated otherwise.