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. 2013 Jul 22;8(7):e70088. doi: 10.1371/journal.pone.0070088

Figure 6. Sepiapterin (SEP) decreased LDH activity and increased NO production, tetrahydrobiopterin, and the ratio of eNOS dimer/monomer in the presence of high glucose (HG) after hypoxia and reoxygenation.

Figure 6

(A) LDH activity normalized to cardiomyocytes (CMs) alone; (B) NO production; (C) tetrahydrobiopterin; (D) ratio of eNOS dimer/monomer [bottom: representative Western blot bands of eNOS dimer and monomer from the extract of co-cultured CMs and endothelial cells (ECs)]. NG = normal glucose media; L-NMMA = L-NG-monomethyl arginine. *P < 0.05 vs. HG; †P < 0.05 vs. HG+SEP (n = 4–9 dishes/group).