Figure 6. Eos secrete a soluble factor(s) to enhance HMCL proliferation.

MV and exosomes were isolated from BM Eos SN. S1 and S2 are the MV-free and exosome-free supernatants, respectively. The various fractions were tested for their ability to stimulate HMCL proliferation as assessed by [3H]TdR-incorporation assay. Results are representative of 3 independent experiments. * p<0.01; ** p<0.001; n.s., not significant.