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. 2013 Jun;6(6):31–37.

TABLE 2.

Retrospective analyses detailing patient characteristics

STUDY (LOCATION AND YEAR) NUMBER OF PATIENTS (TIME PERIOD WHERE PATIENTS WILL BE ENROLLED) MOST COMMON CAUSATIVE DRUGS LATENCY PERIOD RANGE (MEAN) IN DAYS TREATMENT
Chen et al (Taiwan 2010)28 38 (18 men and 20 women) March 2004–January 2009

  • Allopurinol (32%)

  • Phenytoin (18%)

  • Dapsone (17%)

  • CBZ, cotrimoxazole, penicillin, NSAIDs (5% each)

  • Lamotrigine, antituberculous drugs, Chinese drugs (3% each)

 3–76 (20.7)

  • Systemic CTS—45 (75%) (either methylprednisone or oral prednisone)

  • IVIG—2 out of the 45—one recovered and one died

  • Antibiotics—6 patients

  • Only supportive care—10 patients
Um et al (Korea 2010)29 60 (26 men and 34 women) June 1998–May 2008

  • Anticonvulsants (47.4%)

  • Antibiotics (18.4%)

  • NSAIDs (13.2%)

  • Allopurinol (5.3%)

  • Undetermined agents (15.8%)

 3–105 (25.2)

  • Systemic CTS—42.1% (one patient died of opportunistic infection, one patient had progressive deterioration of liver damage)

  • Topical CTS + antihistamines—57.9%

  • Complete recovery—36 (94.8%)
Chiou et al (Taiwan 2008)26 30 (15 men and 15 women) Jan 2001–June 2006

  • Allopurinol 11 (36.7%)

  • CBZ 6(20%)

  • Phenytoin, indomethacin, vancomycin 2 (6.67%)

  • Levamisole, dapsone 1(3.33%)

  • Undetermined 3(10%)

 3–60 (23.49)

  • Systemic CTS—22 (76%)

  • Oral histamine and supportive care—7 (24%)
Eshki et al (France 2009)24 15 (5 men and 10 women) Jan 1995–Dec 2006

  • Allopurinol 4 (27%)

  • Minocycline 3 (20%)

  • Anticonvulsants 3 (20%)

  • Sulfonamides 2 (13.3%)

  • Others 2(13.3%)

 5–95 (18)

  • Systemic CTS—10 (67%)

  • IVIG—3 (20%)

  • Liver transplant—1 (6.7%)

CBZ=Carbamazepine; CTS=corticosteroids; IVIG=intravenous immunoglobulin; EM= erythema multiforme; DM=Diabetes mellitus