TABLE 4.

Japanese group’s criteria for diagnosis of DRESS/DIHS30

Maculopapular rash developing >3 weeks after starting with the suspected drug

Prolonged clinical symptoms 2 weeks after discontinuation of the suspected drug

Fever >38°C

Liver abnormalities (alanine aminotransferase>100U/L)

Leucocyte abnormalities

Leucocytosis (>11 X 109/L)

Atypical lymphocytosis (>5%)

Eosinophilia (>1.5 x 109 /L)

Lymphadenopathy

Human Herpes 6 reactivation

The diagnosis is confirmed by the presence of the 7 criteria (typical DHS).