Table 6. The most enriched timepoint-specific Molecular Function terms in HMDM or Jurkat cells either at 6 or 24 h timepoints.
Fold | p-value | |
HMDM 6 h | ||
GO:0016866∼intramolecular transferase activity | 4.88 | 0.000 |
GO:0019899∼enzyme binding | 1.50 | 0.001 |
GO:0017076∼purine nucleotide binding | 1.22 | 0.001 |
GO:0004721∼phosphoprotein phosphatase activity | 1.96 | 0.002 |
GO:0005096∼GTPase activator activity | 1.75 | 0.003 |
GO:0032553∼ribonucleotide binding | 1.20 | 0.004 |
GO:0032555∼purine ribonucleotide binding | 1.20 | 0.004 |
GO:0000166∼nucleotide binding | 1.17 | 0.005 |
GO:0003711∼transcription elongation regulator activity | 4.07 | 0.006 |
GO:0016791∼phosphatase activity | 1.64 | 0.006 |
HMDM 24 h | ||
GO:0003735∼structural constituent of ribosome | 2.590 | 0.000 |
GO:0032395∼MHC class II receptor activity | 8.422 | 0.000 |
GO:0046915∼transition metal ion transmembrane transporter activity | 3.743 | 0.001 |
GO:0000287∼magnesium ion binding | 1.457 | 0.002 |
GO:0046983∼protein dimerization activity | 1.393 | 0.003 |
GO:0008092∼cytoskeletal protein binding | 1.400 | 0.004 |
GO:0015082∼di-, tri-valent inorganic cation transmembrane transporter activity | 2.850 | 0.004 |
GO:0015149∼hexose transmembrane transporter activity | 3.930 | 0.006 |
GO:0042802∼identical protein binding | 1.319 | 0.007 |
GO:0015145∼monosaccharide transmembrane transporter activity | 3.723 | 0.008 |
Jurkat 6 h | ||
GO:0004812∼aminoacyl-tRNA ligase activity | 5.977 | 0.000 |
GO:0016875∼ligase activity, forming carbon-oxygen bonds | 5.977 | 0.000 |
GO:0016876∼ligase activity, forming aminoacyl-tRNA and related compounds | 5.977 | 0.000 |
GO:0003723∼RNA binding | 1.727 | 0.000 |
GO:0003677∼DNA binding | 1.335 | 0.000 |
GO:0051087∼chaperone binding | 6.973 | 0.000 |
GO:0060590∼ATPase regulator activity | 12.729 | 0.000 |
GO:0000049∼tRNA binding | 6.874 | 0.001 |
GO:0015175∼neutral amino acid transmembrane transporter activity | 6.546 | 0.002 |
GO:0070035∼purine NTP-dependent helicase activity | 2.835 | 0.003 |
Jurkat 24 h | ||
GO:0004860∼protein kinase inhibitor activity | 12.965 | 0.001 |
GO:0019210∼kinase inhibitor activity | 12.615 | 0.001 |
GO:0019207∼kinase regulator activity | 6.088 | 0.003 |
GO:0019887∼protein kinase regulator activity | 5.834 | 0.010 |
GO:0004857∼enzyme inhibitor activity | 2.861 | 0.021 |
GO:0004672∼protein kinase activity | 2.023 | 0.026 |
GO:0004674∼protein serine/threonine kinase activity | 2.196 | 0.038 |
GO:0047115∼trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity | 46.674 | 0.042 |
GO:0032403∼protein complex binding | 2.858 | 0.058 |
GO:0001948∼glycoprotein binding | 7.569 | 0.059 |
Fold: fold enrichment of the GO term based on comparison between the ratios of the differentially regulated genes that belong to a given GO-term and all genes measured that belong to this particular GO-term.
p-value: EASE score p-value indicating the statistical significance of the fold enrichment.
Table has been sorted based on the ascending sum of the p-values for each term.