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. 2013 Jul 22;8(7):e68415. doi: 10.1371/journal.pone.0068415

Table 6. The most enriched timepoint-specific Molecular Function terms in HMDM or Jurkat cells either at 6 or 24 h timepoints.

Fold p-value
HMDM 6 h
GO:0016866∼intramolecular transferase activity 4.88 0.000
GO:0019899∼enzyme binding 1.50 0.001
GO:0017076∼purine nucleotide binding 1.22 0.001
GO:0004721∼phosphoprotein phosphatase activity 1.96 0.002
GO:0005096∼GTPase activator activity 1.75 0.003
GO:0032553∼ribonucleotide binding 1.20 0.004
GO:0032555∼purine ribonucleotide binding 1.20 0.004
GO:0000166∼nucleotide binding 1.17 0.005
GO:0003711∼transcription elongation regulator activity 4.07 0.006
GO:0016791∼phosphatase activity 1.64 0.006
HMDM 24 h
GO:0003735∼structural constituent of ribosome 2.590 0.000
GO:0032395∼MHC class II receptor activity 8.422 0.000
GO:0046915∼transition metal ion transmembrane transporter activity 3.743 0.001
GO:0000287∼magnesium ion binding 1.457 0.002
GO:0046983∼protein dimerization activity 1.393 0.003
GO:0008092∼cytoskeletal protein binding 1.400 0.004
GO:0015082∼di-, tri-valent inorganic cation transmembrane transporter activity 2.850 0.004
GO:0015149∼hexose transmembrane transporter activity 3.930 0.006
GO:0042802∼identical protein binding 1.319 0.007
GO:0015145∼monosaccharide transmembrane transporter activity 3.723 0.008
Jurkat 6 h
GO:0004812∼aminoacyl-tRNA ligase activity 5.977 0.000
GO:0016875∼ligase activity, forming carbon-oxygen bonds 5.977 0.000
GO:0016876∼ligase activity, forming aminoacyl-tRNA and related compounds 5.977 0.000
GO:0003723∼RNA binding 1.727 0.000
GO:0003677∼DNA binding 1.335 0.000
GO:0051087∼chaperone binding 6.973 0.000
GO:0060590∼ATPase regulator activity 12.729 0.000
GO:0000049∼tRNA binding 6.874 0.001
GO:0015175∼neutral amino acid transmembrane transporter activity 6.546 0.002
GO:0070035∼purine NTP-dependent helicase activity 2.835 0.003
Jurkat 24 h
GO:0004860∼protein kinase inhibitor activity 12.965 0.001
GO:0019210∼kinase inhibitor activity 12.615 0.001
GO:0019207∼kinase regulator activity 6.088 0.003
GO:0019887∼protein kinase regulator activity 5.834 0.010
GO:0004857∼enzyme inhibitor activity 2.861 0.021
GO:0004672∼protein kinase activity 2.023 0.026
GO:0004674∼protein serine/threonine kinase activity 2.196 0.038
GO:0047115∼trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity 46.674 0.042
GO:0032403∼protein complex binding 2.858 0.058
GO:0001948∼glycoprotein binding 7.569 0.059

Fold: fold enrichment of the GO term based on comparison between the ratios of the differentially regulated genes that belong to a given GO-term and all genes measured that belong to this particular GO-term.

p-value: EASE score p-value indicating the statistical significance of the fold enrichment.

Table has been sorted based on the ascending sum of the p-values for each term.