Table 2. Identified genes in A. xylosoxidans NH44784-1996 involved in pathogenicity.
| Product | No. of genes | Gene name/Abbrev. | A8 | PAO1 | J2315 | K-12 |
|---|---|---|---|---|---|---|
| Protein secretion | ||||||
| Type II | ||||||
| General secretion pathway | 20 | Type C,D,E,F,G,H,I,J,K,L,M,N | X | X, except N | X | X, except N |
| Type III | ||||||
| Outermembrane pore forming protein | 1 | YscC,MxiD,HrcC, InvG | - | X | X | - |
| Inner membrane protein | 1 | YscU,SpaS,EscU,HrcU,SsaU | - | X | X | - |
| Inner membrane protein | 1 | YscT,HrcT,SpaR,EscT,EpaR1 | - | X | X | - |
| Inner membrane protein | 1 | YscS | - | X | X | - |
| Inner membrane protein | 1 | YscR,SpaR,HrcR,EscR | - | X | X | - |
| Inner membrane protein | 1 | YscQ | - | X | X | - |
| Spans bacterial envelope protein | 1 | YscO | - | X | - | - |
| Cytoplasmic protein | 1 | YscL | - | X | X | - |
| Putative type III secretion protein | 3 | - | - | - | - | - |
| Bridge between inner and outermembrane lipoprotein | 1 | YscJ,HrcJ,EscJ, PscJ | - | X | X | - |
| Chaperone protein for YopD | 1 | SycD | - | X | - | - |
| Cytoplasmic LcrG inhibitor | 1 | LcrV | - | X | - | - |
| Inner membrane channel protein | 1 | LcrD,HrcV,EscV,SsaV | - | X | X | - |
| Type VI | ||||||
| ClpB protein | 1 | ClpB | X | X | X | - |
| IcmF-related protein | 1 | IcmF | X | X | X | - |
| Protein ImpG/VasA | 1 | ImpG | X | X | X | - |
| Sigma-54 dependent transcriptional regulator | 1 | - | X | X | - | - |
| Uncharacterized protein ImpA | 1 | ImpA | X | X | X | - |
| Uncharacterized protein ImpB | 1 | ImpB | X | X | X | - |
| Uncharacterized protein ImpC | 1 | ImpC | X | X | X | - |
| Uncharacterized protein ImpD | 1 | ImpD | X | X | - | - |
| Uncharacterized protein ImpF | 1 | ImpF | X | X | X | - |
| Uncharacterized protein ImpH/VasB | 1 | ImpH | X | X | X | - |
| Uncharacterized protein ImpJ/VasE | 1 | ImpJ | X | X | X | - |
| VgrG protein | 1 | VgrG | X | X | X | - |
| Type VII | ||||||
| Sigma-fimbriae chaperone protein | 1 | - | X | X | X | - |
| Sigma-fimbriae tip adhesin | 1 | - | X | X | X | - |
| Sigma-fimbriae usher protein | 1 | - | X | X | X | - |
| Adhesion | ||||||
| PGA outer membrane secretin | 1 | PgaA | X | - | X | X |
| PGA synthesis deacetylase | 1 | PgaB | X | - | X | X |
| PGA synthesis N-glycosyltransferase | 1 | PgaC | X | - | X | X |
| PGA synthesis auxiliary protein | 1 | PgaD | - | - | X | X |
| Denitrification | ||||||
| Nitrous oxide reductase maturation protein | 3 | NosD NosF NosR | X | X | - | - |
| Nitrous oxide reductase maturation protein, outer-membrane lipoprotein | 1 | NosL | X | X | - | - |
| Nitrous oxide reductase maturation transmembrane protein | 1 | NosY | X | X | - | - |
| Nitrous-oxide reductase (EC 1.7.99.6) | 1 | - | X | X | - | - |
| Protein involved in response to NO | 1 | NnrS | X | X | - | - |
| Copper-containing nitrite reductase (EC 1.7.2.1) | 1 | - | X | X | - | - |
| Nitric oxide -responding transcriptional regulator | 1 | NnrR (Crp/Fnr family) | X | X | - | - |
| Nitric-oxide reductase (EC 1.7.99.7), quinol-dependent | 1 | - | X | X | - | - |
| Nitrite reductase accessory protein | 1 | NirV | X | X | - | - |
| Nitrous oxide reductase maturation periplasmic protein | 1 | NosX | X | X | - | - |
An X refers to the presence of the gene in A. xylosoxidans A8, P. aeruginosa PAO1, B. cenocepacia J2315 or E. coli K-12.